The main difference between a missiles tens or hundreds of kilometers away and a drone with a missile is the flight time. A lot of things can happen even if you

The main difference between a missiles tens or hundreds of kilometers away and a drone with a missile is the flight time. A lot of things can happen even if you fly at the speed Mach 1 or about 0.3km/s. If we assume 50km away, it means targets has 3 minutes to do something which turn the attack from great to terrible.