4 ms·
TLDR: Sleep deprivation in flies and mice leads to increased ROS (Reactive oxygen species) molecules in the gut. This is show to be highly correalted to be the
by seesawtron 6y ago
TLDR: Sleep deprivation in flies and mice leads to increased ROS (Reactive oxygen species) molecules in the gut. This is show to be highly correalted to be the cause of lethality. To show the causality, the over-expression of anti-oxiodants restores normal lifespan in the animals.
Abstract video summary by the senior author here:
https://bit.ly/3cy0C9u https://bit.ly/3cy0C9u
- sradman 6y agoThe Cell paper [1] begins with a three bullet Highlights section: - Sleep deprivation leads to ROS accumulation in the fly and mouse gut - Gut-accumulated ROS trigger oxidative stress in this organ - Preventing ROS accumulation in the gut allows survival without sleep in flies [1] https://www.cell.com/cell/pdf/S0092-8674(20)30555-9.pdf?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0092867420305559%3Fshowall%3Dtrue https://www.cell.com/cell/pdf/S0092-8674(20)30555-9.pdf?_ret...