Indeed, it doesn't help post exposure. UMN is doing two other trials, one for pre exposure and one for treatment. IIRC, all of them do not use zinc or macrolide

Indeed, it doesn't help post exposure. UMN is doing two other trials, one for pre exposure and one for treatment. IIRC, all of them do not use zinc or macrolides. (Some patients of the post exposure prophylaxis trial used zinc, but there's no statistical difference without, although the authors warn about confounding factors). Some important limitations of the study, results notwithstanding: - There were basically no PCR-confirmed tests, due to lack of testing materials, and patients reported symptoms themselves - The whole thing (reporting) was done via email or telephone, no in person checks (even HCQ or placebo was shipped to the participants) David Boulware (the study's PI) on Twitter, a couple of weeks ago, complained that he sought funding from the NIH for this trial, but he got none. I thought it was all said and done for post exposure prophylaxis, but at least NEJM's editor is not of the same opinion, and mentions that even in this field of application there are still unknowns[1]. There are larger trials going on, like UK's RECOVERY, which will likely give firmer answers. [1] https://www.nejm.org/doi/full/10.1056/NEJMe2020388 https://www.nejm.org/doi/full/10.1056/NEJMe2020388