3 ms·
> My guess right now is that at best it will be as effective as remdesivir, but really until an actual RCT is conducted there is no proof either way. By now, i
by lbeltrame 6y ago
> My guess right now is that at best it will be as effective as remdesivir, but really until an actual RCT is conducted there is no proof either way.
By now, it also matters when you give it. Lopinavir/ritonavir were called ineffective in NEJM, but a recent publication (in Lancet, ironically) says that perhaps (no placebo, blech) that given within 7 days of symptom onset they may be beneficial.
Remedisivir looks best in patients with moderate (requiring oxygen) but not critical disease.
And as for RCTs on HCQ, one of those (for post-exposure prophylaxis) from UMN should be apparently be published soon (no idea when or how: their PI is being, IMO rightly so, tight-lipped), and another is under review. A third one is ongoing.