10 ms·

Looked at both your links 1. Seems to be saying there isn’t currently a health risk posed by the continuing of their trial. 2. Says they tried using HCQ and P

Looked at both your links 1. Seems to be saying there isn’t currently a health risk posed by the continuing of their trial. 2. Says they tried using HCQ and PPE together and found health providers were catching the virus less. Nothing in the article attempts to break out whether HCQ or PPE was responsible for it - obviously it’s common sense that using PPE would reduce the risk of catching the virus. This is hardly a truckload of evidence at all. Also the original study from France was about using HCQ for patients who had already caught the virus, not prophylactic use. HCQ proponents shift around between possible uses of the drug as it becomes clearer that there is a lack of evidence for one way to use it. Could evidence be found in the future that the drug has some small beneficial effect? It’s possible - but what’s clear is that claims that it was a miracle cure are completely unfounded.

lenkite 6y ago
Yes, I guess I should have posted the other links apart from the French study. Apologies. There is also a massive ongoing study in India which is expected to post findings by July end. Statement from American Journal of Epidemiology, https://academic.oup.com/aje/advance-article/doi/10.1093/aje/kwaa093/5847586 https://academic.oup.com/aje/advance-article/doi/10.1093/aje... Statement from Yale https://medicine.yale.edu/yigh/news-article/25085/ https://medicine.yale.edu/yigh/news-article/25085/ HCQ Studies https://www.medrxiv.org/content/10.1101/2020.03.22.20040758v3 https://www.medrxiv.org/content/10.1101/2020.03.22.20040758v... https://www.medrxiv.org/content/10.1101/2020.04.27.20073379v1 https://www.medrxiv.org/content/10.1101/2020.04.27.20073379v... The older study on SARS https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1232869/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1232869/
- javagram 6y ago
  Ongoing studies should continue and we can see if there is an provable effect, now that the claim of health danger has been discredited. My guess right now is that at best it will be as effective as remdesivir, but really until an actual RCT is conducted there is no proof either way. The only thing I’m sure of it isn’t a “100%” cure as was touted by some politicians since if so, that would be obvious by now as the drug has been tried since January/February and yet patients treated with it are still dying.
  - lbeltrame 6y ago
    > My guess right now is that at best it will be as effective as remdesivir, but really until an actual RCT is conducted there is no proof either way. By now, it also matters when you give it. Lopinavir/ritonavir were called ineffective in NEJM, but a recent publication (in Lancet, ironically) says that perhaps (no placebo, blech) that given within 7 days of symptom onset they may be beneficial. Remedisivir looks best in patients with moderate (requiring oxygen) but not critical disease. And as for RCTs on HCQ, one of those (for post-exposure prophylaxis) from UMN should be apparently be published soon (no idea when or how: their PI is being, IMO rightly so, tight-lipped), and another is under review. A third one is ongoing.

lenkite 6y ago

Yes, I guess I should have posted the other links apart from the French study. Apologies. There is also a massive ongoing study in India which is expected to post findings by July end. Statement from American Journal of Epidemiology, https://academic.oup.com/aje/advance-article/doi/10.1093/aje/kwaa093/5847586 https://academic.oup.com/aje/advance-article/doi/10.1093/aje... Statement from Yale https://medicine.yale.edu/yigh/news-article/25085/ https://medicine.yale.edu/yigh/news-article/25085/ HCQ Studies https://www.medrxiv.org/content/10.1101/2020.03.22.20040758v3 https://www.medrxiv.org/content/10.1101/2020.03.22.20040758v... https://www.medrxiv.org/content/10.1101/2020.04.27.20073379v1 https://www.medrxiv.org/content/10.1101/2020.04.27.20073379v... The older study on SARS https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1232869/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1232869/

javagram 6y ago
Ongoing studies should continue and we can see if there is an provable effect, now that the claim of health danger has been discredited. My guess right now is that at best it will be as effective as remdesivir, but really until an actual RCT is conducted there is no proof either way. The only thing I’m sure of it isn’t a “100%” cure as was touted by some politicians since if so, that would be obvious by now as the drug has been tried since January/February and yet patients treated with it are still dying.
- lbeltrame 6y ago
  > My guess right now is that at best it will be as effective as remdesivir, but really until an actual RCT is conducted there is no proof either way. By now, it also matters when you give it. Lopinavir/ritonavir were called ineffective in NEJM, but a recent publication (in Lancet, ironically) says that perhaps (no placebo, blech) that given within 7 days of symptom onset they may be beneficial. Remedisivir looks best in patients with moderate (requiring oxygen) but not critical disease. And as for RCTs on HCQ, one of those (for post-exposure prophylaxis) from UMN should be apparently be published soon (no idea when or how: their PI is being, IMO rightly so, tight-lipped), and another is under review. A third one is ongoing.