3 ms·

I'm just slightly surprised that the study wasn't made randomized. I can't see any ethical reason why that couldn't have been done but maybe there were logistic

I'm just slightly surprised that the study wasn't made randomized. I can't see any ethical reason why that couldn't have been done but maybe there were logistical reasons. Larger randomized trials are in progress [1][2] but the results won't be published until July. [1] https://clinicaltrials.gov/ct2/show/NCT04344041 https://clinicaltrials.gov/ct2/show/NCT04344041 [2] https://clinicaltrials.gov/ct2/show/NCT04351490 https://clinicaltrials.gov/ct2/show/NCT04351490.

MiroF 6y ago
Because it's an observational study? It wasn't an experiment. They couldn't make it randomizes. This is often the first stage before an RCT. Don't see what's confusing about this.
- spuz 6y ago
  The study authors decided to administer DMB to all patients who arrived for treatment at the hospital after a certain date - I don't see why they could not have decided to administer DMB to 50% of patients and turn the study from an observational study into an RCT. > As the COVID-19 situation evolved, we decided from 6 April 2020, to start DMB on all COVID-19 patients above 50 years old upon hospitalization and before the onset of the primary outcome event. Patients admitted during this period who did not receive DMB before event onset were served as control. Therapy comprised a single daily oral dose of vitamin D3 1000 IU, magnesium 150mg and vitamin B12 500mcg for up to 14 days