"Powerful psychoactive substances shouldn't be taken by people who are not mentally 'balanced', meaning just fine, happy with themselves or similar." But there

"Powerful psychoactive substances shouldn't be taken by people who are not mentally 'balanced', meaning just fine, happy with themselves or similar." But therein lies the crux of this kind of reasoning: those kinds of requirements are vague and highly subjective - what does "mentally balanced" entail? who determines that? It would require a high level of self-awareness and even then, some woundings/mental illnesses may not be apparent until some sort of traumatic event (such as a bad trip). It's incredibly difficult to know ahead of time what kind of reaction someone is going to have to such powerful mind-altering substances and IMO although the advice of "set and setting" is important, it in no way will prevent all possible issues from happening.