3 ms·
FTA: In mice, when Dr. Isenberg and his team introduced a drug that prevented a protein, thrombospondin-1, from binding to a surface cell receptor called CD47,
by miles 16y ago
FTA: In mice, when Dr. Isenberg and his team introduced a drug that prevented a protein, thrombospondin-1, from binding to a surface cell receptor called CD47, the animals could endure almost unheard-of doses of radiation with virtually no ill effects.
This is from late 2009. Does anyone have an update on this research? Would obviously be a great boon if it was equally effective in humans.
- anigbrowl 16y agohttp://www.radiationcontroltherapies.com/news-and-updates.html http://www.radiationcontroltherapies.com/news-and-updates.ht...
- miles 16y agoVery cool - thanks! Looks like the latest update is that "The CCR-NCI of the NIH recently recognized the work of Dr. Isenberg and collaborators in controlling radiation by CD47 blockade as one of the 'top science advances for 2010'". Nice to hear that the work is apparently regarded as credible. Hope to hear more about it soon!
- biot 16y agoIt would be ironic if this therapy causes increased risk of cancer, for which chemotherapy then has little effect. Then again, if the resistance is temporary I imagine some workers in Fukushima might benefit from this once it's been demonstrated safe enough.
- kajecounterhack 16y agoGo to the second page "Perhaps equally exciting, Dr. Isenberg and his team found that while his technique protected healthy cells from damage, it actually increased the effectiveness of radiation treatments on cancer cells."
- bedris 16y agoThis could also be due to the fact that CD47 blockade allows preferential phagocytosis of cancer cells by macrophages [1,2] so it might not be solely radiation sensitivity that is leading to the clearance of the tumor cells. [1] http://www.ncbi.nlm.nih.gov/pubmed/19632179 http://www.ncbi.nlm.nih.gov/pubmed/19632179 [2] http://www.ncbi.nlm.nih.gov/pubmed/19632178 http://www.ncbi.nlm.nih.gov/pubmed/19632178
- rbanffy 16y ago"safe enough" as in "safer than standard treatment". In their place, I'd prefer a taste for cheese and an overwhelming fear of cats to radiation sickness.
- GrandMasterBirt 16y agoChemotherapy is not rad therapy. Diff methods, both pretty effective in hurting healthy cells.
- biot 16y agoYou learn something new every day... radiotherapy is the radiation treatment. For some reason I thought chemotherapy included the radiation part.