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The use of human challenges get trials is a very different situation, and the decision of whether or not to engage in one is definitely a question where economi
by vikramkr 6y ago
The use of human challenges get trials is a very different situation, and the decision of whether or not to engage in one is definitely a question where economists and ethicists have a lot to contribute, I'm glad you're engaged in the conversation. Its a tough utility/risk-reward/ethics question, where we'd be able to speed up development of immunization approaches by a LOT, but with a virus we still don't fully understand and that keeps surprising us. Definitely a decision that needs cross discipline input and discussion.
- cameldrv 6y agoIt's not a totally different situation. In fact, since with a human challenge trial, you're probably going to be inoculating both arms of the trial with a variable dose, you can use the data from the control arm of the challenge trial as essentially a phase 1 of the variolation trial.