4 ms·
The dose for malaria is 200mg. It's the higher doses that are associated with heart arythmia in covid patients. According to a trial reported in https://bmcmedi
by vixen99 6y ago
The dose for malaria is 200mg. It's the higher doses that are associated with heart arythmia in covid patients. According to a trial reported in https://bmcmedicine.biomedcentral.com/track/pdf/10.1186/s12916-018-1188-2 https://bmcmedicine.biomedcentral.com/track/pdf/10.1186/s129...
"No serious cardiac adverse effects were recorded in malaria clinical trials of 35,548 participants who received quinoline and structurally related antimalarials with close follow-up including 18,436 individuals who
underwent ECG evaluation."
"Chloroquine is the most widely used antimalarial drug
in history. It has a terminal elimination half-life of
one month and an annual consumption of hundreds of
tonnes for over 50 years, so it may be the drug to which
humans have been exposed to most. Despite producing consistent QT prolongation, the only case reports
of TdP and sudden death have been for its use for
non-malaria indications such as systemic lupus erythematosus or rheumatoid arthritis, where high doses are
used for much longer than in malaria treatment, or in
overdose"
- marvin 6y agoUnless I'm mistaken, this paper refers to chloroquine, not hydroxychloroquine. They are often conflated in the media and colloquial reporting.