4 ms·

The risk of treating patients with pain-reducing levels of ASA (aspirin) is actually a significant issue, and it's not hard to find papers covering this issue,

The risk of treating patients with pain-reducing levels of ASA (aspirin) is actually a significant issue, and it's not hard to find papers covering this issue, and reporting data on it. It's usually in older populations who are more likely to be in pain and also more likely to die from a stomach bleed.

cm2187 6y ago
Yeah. But like every drug in the world has contraindications. By this standard all drugs are dangerous and should be banned from trials.
- frenchyatwork 6y ago
  I think I misunderstood you. I thought you were suggesting we should give drugs to people regardless of the fact that the randomized controlled trials say that the drug doesn't provide any significant benefit. Giving widespread ASA to a population that wouldn't benefit from it would be a bad idea.
  - cm2187 6y ago
    Well I am personally in favour of doing randomized control trials, not to cancel them based on what appear to be a weak statistical analysis. There was an argument to not wait at the peak of the epidemic rather than not treating (and some of these trials are only starting, which baffles me). But these trials should have been done from the outset. Doctors in the heat of the moment cannot wait for a randomized trial. They started keeping patients off intrusive ventilators without doing a randomized trial, based on annecdotal evidence. But these trials still need to happen.
    - vharuck 6y ago
      According to most of the countries mentioned in the article, trials of HCQ are still going on. The WHO put its trial on pause. Other countries are just stopping the use of HCQ outside of approved trials.
      - cm2187 6y ago
        I wish it would be the case but for instance in France the drug authority seems to be determined to stop all trials [1] [1] https://www.midilibre.fr/2020/05/26/coronavirus-lagence-du-medicament-suspend-a-son-tour-les-essais-avec-la-chloroquine,8903727.php https://www.midilibre.fr/2020/05/26/coronavirus-lagence-du-m...

cm2187 6y ago

Yeah. But like every drug in the world has contraindications. By this standard all drugs are dangerous and should be banned from trials.

frenchyatwork 6y ago
I think I misunderstood you. I thought you were suggesting we should give drugs to people regardless of the fact that the randomized controlled trials say that the drug doesn't provide any significant benefit. Giving widespread ASA to a population that wouldn't benefit from it would be a bad idea.
- cm2187 6y ago
  Well I am personally in favour of doing randomized control trials, not to cancel them based on what appear to be a weak statistical analysis. There was an argument to not wait at the peak of the epidemic rather than not treating (and some of these trials are only starting, which baffles me). But these trials should have been done from the outset. Doctors in the heat of the moment cannot wait for a randomized trial. They started keeping patients off intrusive ventilators without doing a randomized trial, based on annecdotal evidence. But these trials still need to happen.
  - vharuck 6y ago
    According to most of the countries mentioned in the article, trials of HCQ are still going on. The WHO put its trial on pause. Other countries are just stopping the use of HCQ outside of approved trials.
    - cm2187 6y ago
      I wish it would be the case but for instance in France the drug authority seems to be determined to stop all trials [1] [1] https://www.midilibre.fr/2020/05/26/coronavirus-lagence-du-medicament-suspend-a-son-tour-les-essais-avec-la-chloroquine,8903727.php https://www.midilibre.fr/2020/05/26/coronavirus-lagence-du-m...