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> certainly thought a vaccine was 'a bit of' the thing to immunised against A lot of the original vaccines were made from deactivated viruses. I don't know ho

> certainly thought a vaccine was 'a bit of' the thing to immunised against A lot of the original vaccines were made from deactivated viruses. I don't know how that process works exactly, but your understanding isn't far off at least for how they were originally produced.

twic 6y ago
A lot still are. Sinopharm (the two "Institutes of Biological Products") and Sinovac are both developing inactivated virus vaccines for COVID-19: https://www.who.int/blueprint/priority-diseases/key-action/novel-coronavirus-landscape-ncov.pdf https://www.who.int/blueprint/priority-diseases/key-action/n...
Cactus2018 6y ago
>> were made from deactivated viruses. I don't know how that process works exactly Check out the history of the Rabies vaccine, where the virus was weakened through aging: > derived from the spinal cord of an inoculated rabbit which had died of rabies 15 days earlier. https://en.wikipedia.org/wiki/Rabies_vaccine#History https://en.wikipedia.org/wiki/Rabies_vaccine#History > A vaccine typically contains an agent that resembles a disease-causing microorganism and is often made from weakened or killed forms of the microbe, its toxins, or one of its surface proteins. https://en.wikipedia.org/wiki/Inactivated_vaccine https://en.wikipedia.org/wiki/Inactivated_vaccine > The virus is killed using a method such as heat or formaldehyde. > Whole virus vaccines use the entire virus particle, fully destroyed using heat, chemicals, or radiation. > Split virus vaccines are produced by using a detergent to disrupt the virus. > Subunit vaccines are produced by purifying out the antigens that best stimulate the immune system to mount a response to the virus, while removing other components necessary for the virus to replicate or survive or that can cause adverse reactions
OJFord 6y ago
But my understanding of these Wikipedia pages is that, if the deactivated virus is the same as the one it's designed to immunise against, then the treatment is properly termed an inoculation; not a vaccination (which would strictly speaking imply that it was a deactivated virus B administered in order to protect against a virus A)?

twic 6y ago

A lot still are. Sinopharm (the two "Institutes of Biological Products") and Sinovac are both developing inactivated virus vaccines for COVID-19: https://www.who.int/blueprint/priority-diseases/key-action/novel-coronavirus-landscape-ncov.pdf https://www.who.int/blueprint/priority-diseases/key-action/n...

Cactus2018 6y ago

>> were made from deactivated viruses. I don't know how that process works exactly Check out the history of the Rabies vaccine, where the virus was weakened through aging: > derived from the spinal cord of an inoculated rabbit which had died of rabies 15 days earlier. https://en.wikipedia.org/wiki/Rabies_vaccine#History https://en.wikipedia.org/wiki/Rabies_vaccine#History > A vaccine typically contains an agent that resembles a disease-causing microorganism and is often made from weakened or killed forms of the microbe, its toxins, or one of its surface proteins. https://en.wikipedia.org/wiki/Inactivated_vaccine https://en.wikipedia.org/wiki/Inactivated_vaccine > The virus is killed using a method such as heat or formaldehyde. > Whole virus vaccines use the entire virus particle, fully destroyed using heat, chemicals, or radiation. > Split virus vaccines are produced by using a detergent to disrupt the virus. > Subunit vaccines are produced by purifying out the antigens that best stimulate the immune system to mount a response to the virus, while removing other components necessary for the virus to replicate or survive or that can cause adverse reactions

OJFord 6y ago

But my understanding of these Wikipedia pages is that, if the deactivated virus is the same as the one it's designed to immunise against, then the treatment is properly termed an inoculation; not a vaccination (which would strictly speaking imply that it was a deactivated virus B administered in order to protect against a virus A)?