It's actually even harder, as the starting point is much, much worse. That's the reason the modern vaccines were developed: they are much safer from the very st

It's actually even harder, as the starting point is much, much worse. That's the reason the modern vaccines were developed: they are much safer from the very start. We simply know much more today than at these times, so we can know (almost) exactly what is going on in the building blocks, and actually use the building blocks and track the effects of the building block without ever having the risk of having to handle and manage the more dangerous thing -- the complete, fully functioning and easy to spread virus -- applying it to every human that we want to "protect". In analogy world for the modern vaccines, imagine a science fiction scenario: the evil aliens look like humans, can and want to easily kill them, but look exactly like humans and we don't know how to recognize them. Variolation is like catching them but them setting them free to go around and kill more in order to train us, expecting that it is possible to set free small enough number of them over and over so that in the fight we will "manage somehow" to win and also learn something while fighting, wheres, producing modern vaccines is like just finding out that the evil aliens look differently in infrared light and just teaching us to use infrared cameras to locate them, completely avoiding the real additional fights among the population "just for training." Variolation, as defined in the article, was the best method that we knew a few centuries ago, but now we simply know much more now. And solving the problem is still complicated enough even with the "better start." We want to minimize false alarms, friendly fire etc. practically, we know what we want and how to measure it and we do all we can to minimize the number of bad outcomes.