I agree, the question of how to deal with high uncertainties is definitely task dependent. In your example of a self-driving car the answer is not clear. Howeve

I agree, the question of how to deal with high uncertainties is definitely task dependent. In your example of a self-driving car the answer is not clear. However, for many other tasks its entirely reasonable to have the AI make decisions and then pop it out to human review upon high uncertainty, or just not act on it. In tasks like this AI can be the primary task-doer with the human as the backup.