4 ms·

Chickenpox is another one, it can re-erupt as shingles when older. My googling also turns up herpes, Epstein-Barr, measles(!), HPV, Hep-B [1]... It looks like

Chickenpox is another one, it can re-erupt as shingles when older. My googling also turns up herpes, Epstein-Barr, measles(!), HPV, Hep-B [1]... It looks like there are many diseases which can find a host reservoir in our body to hide out for a while. [1] https://www.ncbi.nlm.nih.gov/books/NBK8538/ https://www.ncbi.nlm.nih.gov/books/NBK8538/

mc32 6y ago
Ebola too, i think would hide in peoples’s eyes and come back in some cases, if I recall correctly.
godelski 6y ago
So there's nuance to this that's important. Let's look at measles[0] because we get vaccinated for it (which shows that we can get immunity) but the report says that 9% of cases were people who had been vaccinated. The crux of this is that immunity doesn't last forever but does last for awhile. In measles it looks like 15 years after your two standard MMR vaccines you get from a kid. We have to recognize too that vaccines aren't perfect. Your immune system might not make as strong of an antibody response as another person. You may lose immunity sooner than others. Etc. But the whole premise of the vaccine is that you can get immunity. And if we look at this study, this worked out for most people. Not many people got measles, and of those that did only 9% were vaccinated, which shows that there is a substantial bias for those that weren't vaccinated. So when I'm saying that people get get immunity I don't mean forever and to every strain, but that they generally get some protection. In fact, this is an essential component to vaccine theory. If you gain __NO__ immunity (for any period of time) from covid, then a vaccine isn't going to do anything because you can't build an immunity. If you get immunity for a year (like with the flu), I think that's a pretty acceptable risk for many and shows that we could build substantial herd immunity just with the younger populations (like with the flu, which the vaccine there isn't even that great, but better than nothing). And as another note on Shingles, I don't know about you, but chickenpox parties (because it is A LOT worse when you're older) were a thing when I was a kid (I'm not even 30!) and less than 1% of people get shingles. The main factors are being old, immunocompromised, and getting chickenpox before you're 18 months old. Saying you can get reinfected and will get reinfected are different statements with different risk values. [0] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4979181/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4979181/

mc32 6y ago

Ebola too, i think would hide in peoples’s eyes and come back in some cases, if I recall correctly.

godelski 6y ago

So there's nuance to this that's important. Let's look at measles[0] because we get vaccinated for it (which shows that we can get immunity) but the report says that 9% of cases were people who had been vaccinated. The crux of this is that immunity doesn't last forever but does last for awhile. In measles it looks like 15 years after your two standard MMR vaccines you get from a kid. We have to recognize too that vaccines aren't perfect. Your immune system might not make as strong of an antibody response as another person. You may lose immunity sooner than others. Etc. But the whole premise of the vaccine is that you can get immunity. And if we look at this study, this worked out for most people. Not many people got measles, and of those that did only 9% were vaccinated, which shows that there is a substantial bias for those that weren't vaccinated. So when I'm saying that people get get immunity I don't mean forever and to every strain, but that they generally get some protection. In fact, this is an essential component to vaccine theory. If you gain __NO__ immunity (for any period of time) from covid, then a vaccine isn't going to do anything because you can't build an immunity. If you get immunity for a year (like with the flu), I think that's a pretty acceptable risk for many and shows that we could build substantial herd immunity just with the younger populations (like with the flu, which the vaccine there isn't even that great, but better than nothing). And as another note on Shingles, I don't know about you, but chickenpox parties (because it is A LOT worse when you're older) were a thing when I was a kid (I'm not even 30!) and less than 1% of people get shingles. The main factors are being old, immunocompromised, and getting chickenpox before you're 18 months old. Saying you can get reinfected and will get reinfected are different statements with different risk values. [0] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4979181/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4979181/