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It sounds easy in theory but most people hate the idea of messing with biology, believing that it should be regulated and professionalised as much as possible.
by ampdepolymerase 6y ago
It sounds easy in theory but most people hate the idea of messing with biology, believing that it should be regulated and professionalised as much as possible. Even on this very forum, the mere suggestion that a PCR machine (basically a glorified slow cooker) can be built with off the shelf parts is enough to invite a flood of downvotes - https://news.ycombinator.com/item?id=22578216 https://news.ycombinator.com/item?id=22578216
The lack of easy commercialisation of biotechnology and regulatory capture in the name of "move fast break things and people die" has resulted in very poor understanding of biochemistry among the general population (most advocates and detractors of vaccines cannot explain how they work or don't work at the chemical level, one of the reasons for the whole Thiomersal controversy). The top minds who do go into this field often do so for the sake of medical school, where the number of places are limited by politics and gatekeeping rather than any practical meritocratic reason. The lack of money and opportunity is a fundamental problem. Currently large numbers of the general population have a damn good understanding of how computers work, thanks in part due to web dev bootcamps and the rise of FAANG driving the industry. The same cannot be said for biology or even organic chemistry. Bill Gates has famously said that he would study biology if he was to go back to school again, but in the current environment it would be doubtful any unicorn-level of fast financial gains/reward can be achieved in biotechnology. He will most likely end up as one of the numerous healthcare workers whose ultimate reward after each day of dealing with a pandemic is orchestrated clapping instead of spearheading vaccine research through his foundation (assuming of course he had not already switched to working as a McKinsey consultant given his family connections). Global pharmaceutical and healthcare research is still currently led by the United States; FDA-approval being the universal standard. Sure there are a couple EU-only projects and some attempts in Asia too, but the world's biotech research and development still operates fundamentally within the system of American capitalism. The dearth of opportunities due to politics, regulatory capture, and general lack of appreciation of biology is as much a tragedy as lack of health insurance. Most people would immediately identify with or quote the various media talking points when it comes to healthcare pricing, but hardly anyone would question why there are such tremendous gatekeeping and lack of competition.
I will also link to my previous comment on this:
https://news.ycombinator.com/item?id=22471482 https://news.ycombinator.com/item?id=22471482
Giving up in the face of ignorance is not good policy so I will continue my advocacy of more open biology and medical education even if my comments succumb to the ego of software engineer hordes.
- darepublic 6y agoI would like to be able to do some DIY biochemistry, I support these open source labs
- ampdepolymerase 6y agoThe strange paradox is that the people who advocate for "peaceful slavery bad, dangerous freedom good" are all-in for deregulation when it comes to guns, psychedelics, and marijuana but you don't hear from them at all when it comes to orphan pharmaceuticals and human drug trials. If you have time to leave giant spoon sculptures around to express displeasure at pharmaceutical corporations, then you also have time to push for legislative change when it comes to right to try.
- xkcd-sucks 6y agoAll these points are correct. But, to be fair, the state of the art in biology is still full of Magic and other nonreproducible effects. Computery people get annoyed if a compilation takes 10 minutes and fails with a cryptic error message. Compare this to an experiment where (for example) you spend a full day harvesting fetal rat hippocampus cells, cultivate them for weeks, and then finally run your experiment which "fails". Did you fail the rat prep? It worked for the wizard postdoc but she has been dissecting tiny little hippocampi for years -- maybe the cells aren't what you think they are. Or maybe, due to some unknown factor (temperature? feeding schedule? co2? mycoplasma? ...), the cells are "unhappy" for... some reason . Etc. More of the same, another month, another year, another replication which may or may not be sufficient to quit the experiment altogether. The systems are not understood well enough to debug; the systems which are easily debuggable are not relevant to the real world. But, it is not difficult to do at home what one does in an academic lab. (corporate labs have a bit more money which shortens the iteration loop a bit but doesn't make it less cryptic) Anecdotally, I got a life science PhD and went into a softwarey career because the iteration loop of biology just plain sucks. When I was in grad school, I had free reign to do absolutely whatever with no oversight (if the bills looked normal) -- and did, for a while. All those cool ideas I had, I am content to let other people have and realize them. I am content to read their papers and to hire them.