The E-4B deploys in parallel with the VC-25 on AF1/2 missions, though to a different destination airport. Except for very short range ( intra-CONUS ) or where

The E-4B deploys in parallel with the VC-25 on AF1/2 missions, though to a different destination airport. Except for very short range ( intra-CONUS ) or where the destination can't handle a 747, when a VC-32 goes instead as the bailout bird. Alternatively, quite often SECDEF will use the E-4B as his personal transport on overseas trips; changes to accommodations were made accordingly. Callsigns are usually something cool such as DOOM25 or FLASH22.