4 ms·
I’m working on a nebulized ethyl alcohol biocidal therapy for SARS-CoV-2 and had to research this (plz see my Twitter for a chronology @jhazani). I’m disappoint
by achillesheels 6y ago
I’m working on a nebulized ethyl alcohol biocidal therapy for SARS-CoV-2 and had to research this (plz see my Twitter for a chronology @jhazani). I’m disappointed the link abstracts the actual mechanism of action, other than a hypothesis that evaporation time and contact time makes a difference. It still does not explain distinctly the effects of contact time, which principally involves the polarity of alcohol which disrupts the viral envelope and “denatures” proteins according to the CDC [1] and their arcane reference text you can only find in a medical school library [2].
In other words, the hypothesis is there is electrostatic attractive forces that rip the buggers apart, in which this “pressure” is quantitatively stronger in the presence of molecular hydrogen bonding, ie greater dipole moments between the aqueous solution and the virus.
(PS our study design will rely on 200 proof absolute ethanol for go-to market simplicity and for lowest surface tension deposition into the alveolar pulmonary region to promote alveolar stability)
[1] https://www.cdc.gov/infectioncontrol/guidelines/disinfection/disinfection-methods/chemical.html https://www.cdc.gov/infectioncontrol/guidelines/disinfection...
[2] Ali Y, Dolan MJ, Fendler EJ, Larson EL. Alcohols. In: Block SS, ed. Disinfection, sterilization, and preservation. Philadelphia: Lippincott Williams &
Wilkins, 2001:229-54.