Remdesivir and GS-441524 triphosphate are nucleoside analogs that inhibit polymerase activity. These are notorious for breeding resistance due to polymerase var

Remdesivir and GS-441524 triphosphate are nucleoside analogs that inhibit polymerase activity. These are notorious for breeding resistance due to polymerase variability amongst viruses. So even if they can get it manufactured, it's is a short term boon and long term, questionable. It's critical to find drugs that target other parts of the virus' life cycle to include in a combination therapy. Source: conversation with Sean Whelan https://en.wikipedia.org/wiki/Sean_Whelan_(scientist) https://en.wikipedia.org/wiki/Sean_Whelan_(scientist)