This seems like the sort of argument that should be distributed in the peer-reviewed literature to scientists, not on a news website. I am far from average in

This seems like the sort of argument that should be distributed in the peer-reviewed literature to scientists, not on a news website. I am far from average in my consumption of medical literature--I read several papers every week and have some (limited) background in biophysics. Nonetheless, this debate is miles over my head. One would need to know a great deal about pharmacology to evaluate this article. There are lots of reasons to use one prodrug over another; likewise, there are a great deal of differences between animal models and humans. See also this reddit comment: http://reddit.com/r/chemistry/comments/fv8p4k/comment/fmhydym http://reddit.com/r/chemistry/comments/fv8p4k/comment/fmhydy...