I'm planning to work on a project like this at some point soon (worm biology is so cheap you can do it in your garage for the price of a Mercedes). The main roa

I'm planning to work on a project like this at some point soon (worm biology is so cheap you can do it in your garage for the price of a Mercedes). The main roadblock I want to work on is to get more connection strength measurements - we already have the full wiring diagram for the worm connectome, but it's not obvious that the connections are all equal strength, they definitely are not. Many labs are trying to image the neurons firing realtime at the whole organism level, but they're stymied by the head which has a hundred or so neurons in very close proximity (and they typically fire at rates faster than 3D imaging modalities can keep up). I'm definitely excited to start working on this in a couple of years! My hopeful guess is that observing the full nervous system while it's firing full throttle is the only way to start understanding the algorithms that are running there. And from there hopefully we can start finding patterns! Needless to say I agree with you. The people who say they have a wiring diagram of the mouse brain need to reign in their enthusiasm. We are not anywhere close to start understanding even a fly or zebrafish brain leave alone a mouse or human one. Sydney Brenner himself agreed (though he's arguably biased towards nematodes).