3 ms·
Hmm. Well the epigenetic aging clock effects are hard to interpret, but they also show recovery of cognitive performance in aged rats treated with their magic p
by Gatsky 6y ago
Hmm. Well the epigenetic aging clock effects are hard to interpret, but they also show recovery of cognitive performance in aged rats treated with their magic plasma fraction. That is kind of exciting.
Nevertheless, there are significant conflicts of interest going on, so confirmatory studies by independent bodies in animal models are required. Then there are the human studies. They obviously want to use the epigenetic clock as a surrogate endpoint in humans, so the trial can be completed in a short time frame. Not sure about that, this is a fairly complicated surrogate endpoint we are talking about. Some more relevant biomarkers of aging in humans which incorporate functional readouts would be required at the very least.
https://www.biorxiv.org/content/10.1101/2020.05.07.082917v1.full.pdf https://www.biorxiv.org/content/10.1101/2020.05.07.082917v1....