4 ms·
From abstract: "Given that accumulating evidence points at cholinergic dysfunction as a driving force of major dementia disorders, our findings mechanistically
by patall 6y ago
From abstract: "Given that accumulating evidence points at cholinergic dysfunction as a driving force of major dementia disorders, our findings mechanistically explain how prolonged use of PPIs may increase incidence of dementia. This call for restrictions for prolonged use of PPIs in elderly, and in patients with dementia or amyotrophic lateral sclerosis."
This is classical A causes B and B causes C, so A leads to C which is something we have had before with amyloid plaques. This does not tell us this is false, but really just a link and nothing more.
Some beautiful day, we will fully understand the cause of dementia. Today is not that day.
- carbocation 6y agoI agree. The conclusions in the abstract are not warranted by the experiments. It's hard to imagine a situation where in silico docking experiments lead to a clinical conclusion such as "This call (sic) for restrictions for prolonged use of PPIs in elderly, and in patients with dementia or amyotrophic lateral sclerosis."
- breischl 6y agoSomewhat tangentially, do you have an opinion on whether PPIs cause dementia, regardless of what the mechanism may be? Reason I ask is that I've been taking them daily for years to control GERD, so I'm wondering if I'm frying my brain. But I'm not really qualified to understand the intricacies of this kind of research. Even further tangent: seems like they may also cause acute kidney injury. Yaaaay. I guess everything is a tradeoff. https://www.ncbi.nlm.nih.gov/pubmed/30779194 https://www.ncbi.nlm.nih.gov/pubmed/30779194
- patall 6y agoSorry but no, I do not have an opinion on that.
- legulere 6y ago> This is classical A causes B and B causes C, so A leads to C Another one is salt intake raises blood pressure and high blood pressure causes heart attacks. The reality is more complicated: https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(16)30467-6/fulltext https://www.thelancet.com/journals/lancet/article/PIIS0140-6...