Did anyone else read this and, experiences colored by startups, immediately begin thinking about an analogous effect in startup organizational developmental dyn

Did anyone else read this and, experiences colored by startups, immediately begin thinking about an analogous effect in startup organizational developmental dynamics? Anyways, to be more on topic, I read this quote from the article: "Because of the founder effect, showing that a particular mutation increases viral transmission in humans is very difficult." Does the author here mean that it is hard to determine whether a mutation increases viral transmission in humans or not because that mutation's survival may not necessarily be the result of genetic fitness but founder effect?