Cross-reactivity of the immune response between the common cold coronavirus and SARS-COV-2 is a really interesting finding if this research is replicated and va

Cross-reactivity of the immune response between the common cold coronavirus and SARS-COV-2 is a really interesting finding if this research is replicated and validated. As they found 34% of their healthy/non-COVID donors had reaction to the COVID virus, that pre-existing immunity might be an important part of why the response to infection is so different in different people. One thing this could be involved in that the paper didn't seem to discuss is antibody dependent enhancement type responses (except not ADE exactly since this wasn't about antibodies, more some cellular response). This sort of "backfiring" of the immune system making the disease worse has been (Controversially) suggested being responsible for the asymptomatic vs symptomatic split. Here's a good read on it: https://www.pnas.org/content/117/15/8218 https://www.pnas.org/content/117/15/8218