4 ms·

Given the extremely high rates of HSV-1 infection (roughly half of everyone 14-49 and more among older people [0]), I'm guessing that it would be difficult to e

by snazz 6y ago

Given the extremely high rates of HSV-1 infection (roughly half of everyone 14-49 and more among older people [0]), I'm guessing that it would be difficult to eradicate it using a vaccine (although I'm certainly not an expert). As a side note, the HPV vaccine only protects against strains 16 and 18 (with some also providing protection against types 6 and 11). That covers the majority of the strains that cause cancer, but it certainly doesn't prevent HPV infections altogether. Remember that HPV is the same virus that causes common and plantar warts as well. A Wikipedia quote: "Most people acquire genital HPV infections at some point in their lives, and about 10% of women are currently infected.[25] A large increase in the incidence of genital HPV infection occurs at the age when individuals begin to engage in sexual activity. As with cutaneous HPVs, immunity to genital HPV is believed to be specific to a specific strain of HPV."[1] I don't think it's possible to get rid of either virus very easily, although vaccines that target the most dangerous types are a good defense. [0] https://www.cdc.gov/nchs/products/databriefs/db304.htm https://www.cdc.gov/nchs/products/databriefs/db304.htm [1] https://en.wikipedia.org/wiki/Human_papillomavirus_infection https://en.wikipedia.org/wiki/Human_papillomavirus_infection

toomuchtodo 6y ago
> Given the extremely high rates of HSV-1 infection (roughly half of everyone 14-49 and more among older people [0]), I'm guessing that it would be difficult to eradicate it using a vaccine (although I'm certainly not an expert). True, it'd be similar to Australia where their cervical cancer rates will decline over decades as older people die and for younger people [1], the HPV vaccine uptake rate was very high. Folks with HSV-1 are likely stuck with it for life unless CRISPR comes to the rescue. > As a side note, the HPV vaccine only protects against strains 16 and 18 (with some also providing protection against types 6 and 11). That covers the majority of the strains that cause cancer, but it certainly doesn't prevent HPV infections altogether. Remember that HPV is the same virus that causes common and plantar warts as well. "GARDASIL 9 is a vaccine indicated in females and males 9 through 45 years of age for the prevention of cervical, vulvar, vaginal, and anal cancers caused by human papillomavirus (HPV) Types 16, 18, 31, 33, 45, 52, and 58; precancerous or dysplastic lesions caused by HPV Types 6, 11, 16, 18, 31, 33, 45, 52, and 58; and genital warts caused by HPV Types 6 and 11." https://www.merckvaccines.com/gardasil9/ https://www.merckvaccines.com/gardasil9/ Disclaimer: I'm a male in my mid 30s who has had Gardasil 9 administered by a medical professional. [1] https://www.theguardian.com/society/2018/oct/03/australia-on-track-to-wipe-out-cervical-cancer-within-20-years https://www.theguardian.com/society/2018/oct/03/australia-on... (The Guardian: "Australia on track to wipe out cervical cancer within 20 years" [2018])
- snazz 6y ago
  I stand corrected on the number of strands of HPV that Gardasil 9 protects against. That's more comprehensive than I remembered (and I've also received it). Thanks for correcting me!
  - selimthegrim 6y ago
    It was updated IIRC (I don't know if the FDA has updated the indication to follow)
- vmception 6y ago
  I'm a male and I paid for Gardasil 9 treatments by a medical professional that lasted through my 26th birthday some time ago. It was a decent bet based on the idea that the money and privilege isn't necessarily going to last forever, while - if I wasn't already exposed to those strains - the vaccine helps. Since then they've expanded the utility to people up to 40 years of age, instead of cutting off at 26. They've said throat cancers in men are linked to HPV - I can figure out how that happens - whereas it was previously benign in men and they were just carriers causing cervical cancers. One more reason to date zoomers! The adult ones are attractive and have their shots, whereas older are basically oblivious and likely part of the group that fought against zoomers getting those shots.

by snazz 6y ago

toomuchtodo 6y ago

> Given the extremely high rates of HSV-1 infection (roughly half of everyone 14-49 and more among older people [0]), I'm guessing that it would be difficult to eradicate it using a vaccine (although I'm certainly not an expert). True, it'd be similar to Australia where their cervical cancer rates will decline over decades as older people die and for younger people [1], the HPV vaccine uptake rate was very high. Folks with HSV-1 are likely stuck with it for life unless CRISPR comes to the rescue. > As a side note, the HPV vaccine only protects against strains 16 and 18 (with some also providing protection against types 6 and 11). That covers the majority of the strains that cause cancer, but it certainly doesn't prevent HPV infections altogether. Remember that HPV is the same virus that causes common and plantar warts as well. "GARDASIL 9 is a vaccine indicated in females and males 9 through 45 years of age for the prevention of cervical, vulvar, vaginal, and anal cancers caused by human papillomavirus (HPV) Types 16, 18, 31, 33, 45, 52, and 58; precancerous or dysplastic lesions caused by HPV Types 6, 11, 16, 18, 31, 33, 45, 52, and 58; and genital warts caused by HPV Types 6 and 11." https://www.merckvaccines.com/gardasil9/ https://www.merckvaccines.com/gardasil9/ Disclaimer: I'm a male in my mid 30s who has had Gardasil 9 administered by a medical professional. [1] https://www.theguardian.com/society/2018/oct/03/australia-on-track-to-wipe-out-cervical-cancer-within-20-years https://www.theguardian.com/society/2018/oct/03/australia-on... (The Guardian: "Australia on track to wipe out cervical cancer within 20 years" [2018])

snazz 6y ago
I stand corrected on the number of strands of HPV that Gardasil 9 protects against. That's more comprehensive than I remembered (and I've also received it). Thanks for correcting me!
- selimthegrim 6y ago
  It was updated IIRC (I don't know if the FDA has updated the indication to follow)
vmception 6y ago
I'm a male and I paid for Gardasil 9 treatments by a medical professional that lasted through my 26th birthday some time ago. It was a decent bet based on the idea that the money and privilege isn't necessarily going to last forever, while - if I wasn't already exposed to those strains - the vaccine helps. Since then they've expanded the utility to people up to 40 years of age, instead of cutting off at 26. They've said throat cancers in men are linked to HPV - I can figure out how that happens - whereas it was previously benign in men and they were just carriers causing cervical cancers. One more reason to date zoomers! The adult ones are attractive and have their shots, whereas older are basically oblivious and likely part of the group that fought against zoomers getting those shots.