Weighing the perk "grants poison immunity" versus the perks "increased armor bonus, durability, and resistances" is indeed the crux of the problem. When is the

Weighing the perk "grants poison immunity" versus the perks "increased armor bonus, durability, and resistances" is indeed the crux of the problem. When is the general improvement in quality of life from replacing armor so great that it outweighs temporarily losing immunity?