You can absolutely do this, many of the best programmers I have met are self taught, and you have an existing college degree that's just going to make you more

You can absolutely do this, many of the best programmers I have met are self taught, and you have an existing college degree that's just going to make you more valuable. You are going to need to sell it though, you need a good looking website highlighting all your projects, link to github and keep your github clean. The way I started was doing freelance projects until you're confident enough to move into enterprise ( somewhat ironic because freelance work typically involves more understanding of every part of the system ... and better skills ). Do projects in the language/technologies that you want to work in and highlight those.