They are different. Spectre is more like a lighter, smaller non-JS version of Bootstrap, but both still provide recognizable "components" like navbars, form inp

They are different. Spectre is more like a lighter, smaller non-JS version of Bootstrap, but both still provide recognizable "components" like navbars, form inputs, dropdowns, tabs and so on which are common to most web sites and applications. Tailwind (and maybe Tachyons, I don't know) is a utility framework, or meta-framework if you like: it provides a toolbox of lower level primitives for spacing, fonts, layouts, colors and so forth, out of which you can build your own custom components (or use a palette of existing ones, like Tailwind UI). Of course Spectre/Foundation/Bootstrap etc have these primitives too, but their base premise is that you have higher level components common to every or most sites, so there is no need to reinvent the wheel by rebuilding the nth navbar or tab menu. YMMV, but probably if you are building, say, a standard "boring" CRUD application and you need to get it out quickly you can get a lot of mileage out of Bootstrap or similar frameworks. There is a ton of work already done for you with things like accessibility and browser compatibility, and while these kinds of sites are a bit samey, that is also a plus in that users don't face a learning curve - a menu or calendar widget will behave like every other menu or calendar widget they've seen. An off the shelf theme or some SASS variable tweaking can provide enough branding differentials. On the other hand if you have very demanding customers/designers who require everything to be pixel perfect and "popping" then something like Tailwind that gives you more low level flexibility with some sensible defaults might be a better fit (honestly though, with these kinds of clients you're probably going to have to mess around with CSS anyway).