Many trials do NOT require patients to come in to take the medication, but there are of course some which are harder to take at home (whether intravenous or int

Many trials do NOT require patients to come in to take the medication, but there are of course some which are harder to take at home (whether intravenous or intrathecal or whatever). But compliance is certainly hard to assess and so important. Your app thought reminds me of "Video Directly Observed Therapy" which is commonly used for things like tuberculosis medications (due to painful combo of lengthy duration of treatment, disproportionately affecting less well-off / well-educated people who are more challenged in compliance, and public health risk if inadequately treated). Several companies have also worked on pills with an component that detects when it's been ingested and beams a signal to a (external) device, thus "confirming" ingestion. Although of course, in a way, compliance is part and parcel of your drug's overall effectiveness. Not to dive into efficacy vs effectiveness and the larger considerations... but what if your drug "works" but nobody can be compliant? Of the top of my head, a few antibiotics are like, dosed 6 times a day, so I'd rather prescribe most patients a different one that's only taken twice a day, even if the 6 times a day antibiotic is technically "better" for their infection.