Does “man-made” include “man-altered”? Serious question, not trying to start a geopolitical war. The reason I ask is that it seems somewhat trivial for a well

Does “man-made” include “man-altered”? Serious question, not trying to start a geopolitical war. The reason I ask is that it seems somewhat trivial for a well funded organization to runs generations of a germ through multiple hosts. A (bad) analogy would be like Gregor Mendel and cross breeding plants. Im not a biologist, hence the question. (Although I did cross-breed a hot pepper with a bell pepper when I was a kid, but that was by accident!)