6 ms·

Yes, but that is where you use epidemiology. If you track down each person in the local area infected with the mutant strain and follow their clinical course yo

Yes, but that is where you use epidemiology. If you track down each person in the local area infected with the mutant strain and follow their clinical course you can work this out. You can also do serology to make sure the immune response is similar, etc. There will always be the possibility that the attenuated strain varies is some major but subtle way from the non-attenuated strains, but this is not something ever seen before with other viruses. If you demand to know everything and the answers to all possible risks up front medical science doesn’t advance.

IdoRA 6y ago
I demand to know enough information to be able to give proper informed consent to study volunteers. I think your ideas are possible, but the likelihood of success is quite low and the effort required to do the proper studies is far greater than you estimate. Our resources are better spent on much more developed programs with better defined odds of success. My helpful closing suggestion is to speak with some epidemiologists and clinical researchers to see if you can get some budgetary efforts for what you propose, or failing that, try to locate a review article or two. Good luck.
- danieltillett 6y ago
  How have you determined the likelihood of success and the effort required? With the economic cost to the USA alone running at $500 billion a month are we really constrained by resources? I have spoken to many scientists and clinicians about this. There is a great deal of activity going on to put this into action.
  - kordlessagain 6y ago
    A bit off subject, but I'm curious if you've ever run across any information that indicates certain length genomic sequences (say 8 nucleotides in a row or so) follow some sort of "order" in their numbering in the entire sequence? https://github.com/kordless/covid19_viz/blob/master/README.md https://github.com/kordless/covid19_viz/blob/master/README.m...

IdoRA 6y ago

I demand to know enough information to be able to give proper informed consent to study volunteers. I think your ideas are possible, but the likelihood of success is quite low and the effort required to do the proper studies is far greater than you estimate. Our resources are better spent on much more developed programs with better defined odds of success. My helpful closing suggestion is to speak with some epidemiologists and clinical researchers to see if you can get some budgetary efforts for what you propose, or failing that, try to locate a review article or two. Good luck.

danieltillett 6y ago
How have you determined the likelihood of success and the effort required? With the economic cost to the USA alone running at $500 billion a month are we really constrained by resources? I have spoken to many scientists and clinicians about this. There is a great deal of activity going on to put this into action.
- kordlessagain 6y ago
  A bit off subject, but I'm curious if you've ever run across any information that indicates certain length genomic sequences (say 8 nucleotides in a row or so) follow some sort of "order" in their numbering in the entire sequence? https://github.com/kordless/covid19_viz/blob/master/README.md https://github.com/kordless/covid19_viz/blob/master/README.m...