I don't know. My lab work was primarily with site directed mutagenesis in DNA viruses (PhiX 174). Production seems like it would be the trickiest part -- How do

I don't know. My lab work was primarily with site directed mutagenesis in DNA viruses (PhiX 174). Production seems like it would be the trickiest part -- How do you produce the capsid in sufficient quantity without the machinery it needs for replication? Maybe you just transfect it into cells. Perhaps you clone some viral genes into the host genome and remove them from the virus? I don't know what this would do with regards to packing the remanent genome into the capsid.