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How is chip fabrication is more scalable than plastic 384-well plates and cotton swabs? Nothing shy of a home pregnancy test is more scalable than qPCR.
by lvs 6y ago
How is chip fabrication is more scalable than plastic 384-well plates and cotton swabs? Nothing shy of a home pregnancy test is more scalable than qPCR.
- predxionbio 6y agoGreat question. This is one of the implementations we're actually developing. One of the challenges with the implementation of testing on this scale is not necessarily on the technology/assay but on implementation. How do you reasonably test millions of folks each and every day, or said another way actually get millions of nasal swabs, saliva, etc on 384 well plate? I think our ultimate approach is much more akin, albeit with a bit more sensor voodoo magic, to a at home pregnancy test than 384-well plate qPCR tests at central labs.
- lvs 6y agoOK well, having used a Biacore perhaps two decades ago, I'll just have to imagine your "magic" must be pretty good to compete with plastic multiwell plates and cotton on a stick.
- aheilbut 6y ago50 or 100 sites, each with say a few dozen liquid handling robots. Let’s say each site runs 200 plates per day.. doesn’t seem unreasonable. The only hard parts are the funding and regulatory requirements.
- vikramkr 6y agoYou're getting downvoted but I think it's a fair question actually. I'd assumed they were referring to tapping into non-stressed supply chains. What you mention is valid though and something I'm curious about as well. Are the consumables reliant on chip fabrication? I don't think PCR machines themselves are scalable, maybe chips are more scalable than the optics systems for qPCR, but a valid point about whether the consumables are more scalable as well.