4 ms·
Retrospective antibody testing should be viewed carefully, given the relatively low specificity (i.e., high rate of false positives). If there’s a high clinica
by ejstronge 6y ago
Retrospective antibody testing should be viewed carefully, given the relatively low specificity (i.e., high rate of false positives).
If there’s a high clinical suspicion (could be relevant in this case, though it may also represent the normal flu), the utility of the testing improves.
- hashmymustache 6y agoWhere are you getting low specificity for antibody tests? Most I’ve seen are 98+% with lower sensitivities.
- ejstronge 6y agoAh, I'd be quite interested seeing your 98+% specificity antibody! Looking at the three out of four FDA EUA-approved serology tests (see https://www.fda.gov/medical-devices/emergency-situations-medical-devices/emergency-use-authorizations#covid19ivd https://www.fda.gov/medical-devices/emergency-situations-med...) most do not report sensitivities up to 98%, with the notable exception of Ortho Vitro, though the diversity of the samples they test isn't described. 1. Cellex - https://www.fda.gov/media/136625/download https://www.fda.gov/media/136625/download 2. Ortho Vitros - https://www.fda.gov/media/136967/download https://www.fda.gov/media/136967/download 3. Chembio - https://www.fda.gov/media/136963/download https://www.fda.gov/media/136963/download