Frontend should definitely be something along the lines of Typescript and React. Typescript's typing support is a good investment for long term UI dev productiv

Frontend should definitely be something along the lines of Typescript and React. Typescript's typing support is a good investment for long term UI dev productivity as the project scales. Native desktop client could utilize the same stack via Electron. Backend could start with Python using a popular all-in-one framework like Django to begin with, and scale towards micro-service architecture over time as components grow in complexity. Heroku is a good all-in-one infrastructure service that takes care of dev-ops for the first year.