3 ms·

See https://www.nature.com/articles/s41591-020-0820-9 https://www.nature.com/articles/s41591-020-0820-9 which concludes that it was a naturally evolved virus ba

by dlgeek 7y ago

See https://www.nature.com/articles/s41591-020-0820-9 https://www.nature.com/articles/s41591-020-0820-9 which concludes that it was a naturally evolved virus based on DNA sequencing.

jnbiche 7y ago
Yes, and that would be entirely consistent with the scenario discussed in my comment. Did you read it? You seem to be responding to some other comment about an engineered virus, which no one here is even discussing. I get the feeling people just skim a few words, and then respond based on their...feelings? intuition? politics?
holopol 7y ago
While the analyses above suggest that SARS-CoV-2 may bind human ACE2 with high affinity, computational analyses predict that the interaction is not ideal7 and that the RBD sequence is different from those shown in SARS-CoV to be optimal for receptor binding. Thus, the high-affinity binding of the SARS-CoV-2 spike protein to human ACE2 is most likely the result of natural selection on a human or human-like ACE2 that permits another optimal binding solution to arise. This is strong evidence that SARS-CoV-2 is not the product of purposeful manipulation. https://www.nature.com/articles/s41591-020-0820-9 https://www.nature.com/articles/s41591-020-0820-9 concludes that since maybe (because computational analysis) it isn't as efficient for the receptor binding it wasn't purposefully manipulated. Maybe making the most efficient virus was not the goal, maybe there were many trials and many attempts to get a virus with certain qualities and this one was a failure that got mishandled. --- Anyway, collecting viruses is had work, as shown in this video from December 10, 2019 by the Shanghai Media Group (SMG, one of China's largest state-owned media): https://www.youtube.com/watch?v=ovnUyTRMERI https://www.youtube.com/watch?v=ovnUyTRMERI The road is bumpy but we must learn to stick to our initial choice when we feel confused and lost. In the past 10 years we have visited every corner of Hubei Province. We explored dozens of undeveloped caves and studied more than 300 types of virus vectors. But I do hope these virus samples will only be preserved for scientific research and will never be used in real life. Because humans need not only the vaccines but also the protection from their nature.

by dlgeek 7y ago

See https://www.nature.com/articles/s41591-020-0820-9 https://www.nature.com/articles/s41591-020-0820-9 which concludes that it was a naturally evolved virus based on DNA sequencing.

jnbiche 7y ago

Yes, and that would be entirely consistent with the scenario discussed in my comment. Did you read it? You seem to be responding to some other comment about an engineered virus, which no one here is even discussing. I get the feeling people just skim a few words, and then respond based on their...feelings? intuition? politics?

holopol 7y ago

While the analyses above suggest that SARS-CoV-2 may bind human ACE2 with high affinity, computational analyses predict that the interaction is not ideal7 and that the RBD sequence is different from those shown in SARS-CoV to be optimal for receptor binding. Thus, the high-affinity binding of the SARS-CoV-2 spike protein to human ACE2 is most likely the result of natural selection on a human or human-like ACE2 that permits another optimal binding solution to arise. This is strong evidence that SARS-CoV-2 is not the product of purposeful manipulation. https://www.nature.com/articles/s41591-020-0820-9 https://www.nature.com/articles/s41591-020-0820-9 concludes that since maybe (because computational analysis) it isn't as efficient for the receptor binding it wasn't purposefully manipulated. Maybe making the most efficient virus was not the goal, maybe there were many trials and many attempts to get a virus with certain qualities and this one was a failure that got mishandled. --- Anyway, collecting viruses is had work, as shown in this video from December 10, 2019 by the Shanghai Media Group (SMG, one of China's largest state-owned media): https://www.youtube.com/watch?v=ovnUyTRMERI https://www.youtube.com/watch?v=ovnUyTRMERI The road is bumpy but we must learn to stick to our initial choice when we feel confused and lost. In the past 10 years we have visited every corner of Hubei Province. We explored dozens of undeveloped caves and studied more than 300 types of virus vectors. But I do hope these virus samples will only be preserved for scientific research and will never be used in real life. Because humans need not only the vaccines but also the protection from their nature.