I wouldn't. When you are using a CMS, generally speaking you will be limited in functionality due to the CMS being your framework. When you code from scratch or

I wouldn't. When you are using a CMS, generally speaking you will be limited in functionality due to the CMS being your framework. When you code from scratch or with an established framework (Symfony, CodeIgniter/Kohana, for PHP) you'll have a lot more freedom. People have had great success using Drupal as a backbone for an application, but I can't suggest it, since you're building upon a CMS, and things can get tricky that way. With that said, you mentioned TYPO3 which has its own PHP Application Framework, FLOW3: http://flow3.typo3.org/ http://flow3.typo3.org/