4 ms·

Only if they form antibodies. Studies have been suggesting that people who get it in asymptomatic form are not all forming antibodies - leaving them wide open t

by kian 7y ago

Only if they form antibodies. Studies have been suggesting that people who get it in asymptomatic form are not all forming antibodies - leaving them wide open to be future communicators of the disease.

falcor84 7y ago
That sounds really interesting, could you please link to more info about this?
- kian 7y ago
  I'll check back in here later with links - didn't save it at the time I was reading through.
koyote 7y ago
Wouldn't that mean that a vaccine is close to impossible? My layman understanding is that a vaccine relies on the body creating antibodies.
- carey 7y ago
  It’s possible and desirable for a vaccine to stimulate antibody production where a “natural” infection would not, which is one of the things that will be tested during their development. An extreme example is infection with the tetanus-causing bacterium clostridium tetani, which doesn’t provide natural immunity at all.
- eindiran 7y ago
  A known failure mode of vaccines is if the person who is being vaccinated lacks the right B cells for creating antibodies matching the antigens on the surface of a pathogen. If the B cells a person has lack the right B Cell receptors, they can't generate the correct antibody response to an antigen, because they can't bind with/identify an antigen in the first place. Additionally, they may lack a sufficient number of antigen naive T cells, which haven't yet become differentiated as T memory cells and effector T cells. But that doesn't mean that it is impossible to create a vaccine: this problem exists already for successful vaccines. For example, the Hepatitis B vaccine has a relatively high failure rate, but is still provides immunity 90+% of the time. It just means that some smallish percentage of the people you vaccinate aren't actually contributing to population immunity. See below for more info: https://en.wikipedia.org/wiki/B_cell https://en.wikipedia.org/wiki/B_cell https://en.wikipedia.org/wiki/Memory_B_cell https://en.wikipedia.org/wiki/Memory_B_cell https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3760154/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3760154/ --> this one is particularly good. A lot of good info in here on how vaccination and "memory" interact. https://www.sciencedirect.com/science/article/pii/S0264410X02004073 https://www.sciencedirect.com/science/article/pii/S0264410X0... EDIT: this one covers the major routes of vaccination failure --> https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4962729/#!po=60.7143 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4962729/#!po=60...
- deleted 7y ago
  [deleted]
irq11 7y ago
There are no studies that have suggested anything like this. There simply has not been sufficient time to perform a study of the type needed to prove such a claim: you would need to gather a cohort of people that you know had the virus, wait for them to recover, then test for antibodies. Moreover, even if the percentage of such people were shockingly high (i.e. over a fraction of a percentage), you would need to conduct a huge survey to distinguish it from error rates on the tests themselves.
steveeq1 7y ago
Or maybe it was a false positive.
mr_toad 7y ago
Forming antibodies (antibody driven adaptive immunity) seems like the most likely way patients are recovering. This would be typical of recovery from Coronavirus infection. https://www.nature.com/articles/s41591-020-0819-2 https://www.nature.com/articles/s41591-020-0819-2 I can’t find any research suggesting that patients (symptomatic of not) are recovering in some other way. And in any case, recovery implies some form of immunity, either innate or adaptive. The virus doesn’t just give up after 14 days.
kaitai 7y ago
To everyone suddenly thinking about antibodies vs T-cells vs whatever else, the podcast "This Week In Virology" discusses some of the difficulties at https://www.microbe.tv/twiv/twiv-602/ https://www.microbe.tv/twiv/twiv-602/ (discussion with Stanley Perlman). A number of other episodes also hit on coronavirus. Listen while you're walking the dog. Another fun seminar is this one by Prof Pamela Bjorkman at Caltech; it's useful to watch the slides with at least one eyeball so not for dog-walking. https://www.youtube.com/watch?v=OBcc_dk9Q9U https://www.youtube.com/watch?v=OBcc_dk9Q9U

by kian 7y ago

falcor84 7y ago

That sounds really interesting, could you please link to more info about this?

kian 7y ago
I'll check back in here later with links - didn't save it at the time I was reading through.

koyote 7y ago

Wouldn't that mean that a vaccine is close to impossible? My layman understanding is that a vaccine relies on the body creating antibodies.

carey 7y ago
It’s possible and desirable for a vaccine to stimulate antibody production where a “natural” infection would not, which is one of the things that will be tested during their development. An extreme example is infection with the tetanus-causing bacterium clostridium tetani, which doesn’t provide natural immunity at all.
eindiran 7y ago
A known failure mode of vaccines is if the person who is being vaccinated lacks the right B cells for creating antibodies matching the antigens on the surface of a pathogen. If the B cells a person has lack the right B Cell receptors, they can't generate the correct antibody response to an antigen, because they can't bind with/identify an antigen in the first place. Additionally, they may lack a sufficient number of antigen naive T cells, which haven't yet become differentiated as T memory cells and effector T cells. But that doesn't mean that it is impossible to create a vaccine: this problem exists already for successful vaccines. For example, the Hepatitis B vaccine has a relatively high failure rate, but is still provides immunity 90+% of the time. It just means that some smallish percentage of the people you vaccinate aren't actually contributing to population immunity. See below for more info: https://en.wikipedia.org/wiki/B_cell https://en.wikipedia.org/wiki/B_cell https://en.wikipedia.org/wiki/Memory_B_cell https://en.wikipedia.org/wiki/Memory_B_cell https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3760154/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3760154/ --> this one is particularly good. A lot of good info in here on how vaccination and "memory" interact. https://www.sciencedirect.com/science/article/pii/S0264410X02004073 https://www.sciencedirect.com/science/article/pii/S0264410X0... EDIT: this one covers the major routes of vaccination failure --> https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4962729/#!po=60.7143 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4962729/#!po=60...
deleted 7y ago
[deleted]

irq11 7y ago

There are no studies that have suggested anything like this. There simply has not been sufficient time to perform a study of the type needed to prove such a claim: you would need to gather a cohort of people that you know had the virus, wait for them to recover, then test for antibodies. Moreover, even if the percentage of such people were shockingly high (i.e. over a fraction of a percentage), you would need to conduct a huge survey to distinguish it from error rates on the tests themselves.

steveeq1 7y ago

Or maybe it was a false positive.

mr_toad 7y ago

Forming antibodies (antibody driven adaptive immunity) seems like the most likely way patients are recovering. This would be typical of recovery from Coronavirus infection. https://www.nature.com/articles/s41591-020-0819-2 https://www.nature.com/articles/s41591-020-0819-2 I can’t find any research suggesting that patients (symptomatic of not) are recovering in some other way. And in any case, recovery implies some form of immunity, either innate or adaptive. The virus doesn’t just give up after 14 days.

kaitai 7y ago

To everyone suddenly thinking about antibodies vs T-cells vs whatever else, the podcast "This Week In Virology" discusses some of the difficulties at https://www.microbe.tv/twiv/twiv-602/ https://www.microbe.tv/twiv/twiv-602/ (discussion with Stanley Perlman). A number of other episodes also hit on coronavirus. Listen while you're walking the dog. Another fun seminar is this one by Prof Pamela Bjorkman at Caltech; it's useful to watch the slides with at least one eyeball so not for dog-walking. https://www.youtube.com/watch?v=OBcc_dk9Q9U https://www.youtube.com/watch?v=OBcc_dk9Q9U