4 ms·
From the paper: A total of 63 patients were included with 32 in the hydroxychloroquine arm. Hydroxychloroquine administration was associated with a need for e
by onlyrealcuzzo 7y ago
From the paper:
A total of 63 patients were included with 32 in the hydroxychloroquine arm.
Hydroxychloroquine administration was associated with a need for escalation of respiratory support level compared to those that did not receive hydroxychloroquine at 5 days (p=0.013).
The same findings were observed in a baseline-matched subgroup analysis. Absolute lymphocyte change in the
hydroxychloroquine group was no different than supportive care alone (p=0.413).
Hydroxychloroquine use trended towards worsening neutrophil-to-lymphocyte ratio compared to supportive care alone
(+9.59 vs +1.58, p=0.51) as well as a higher risk for intubation (p=0.051).
- layoutIfNeeded 7y agop=0.413 p=0.51 So, basically coin toss?
- onlyrealcuzzo 7y agoYou overlooked the major finding of the study: > Hydroxychloroquine administration was associated with a need for escalation of respiratory support level compared to those that did not receive hydroxychloroquine at 5 days (p=0.013). > p = 0.013
- jeremysalwen 7y ago> was no different than supportive care alone (p=0.413). Yes, exactly, p=0.413 corresponds to a coin toss, or as the authors of the paper put it "no different". The p=0.51 figure seems to be a typo in the abstract. If you read the content of the paper, it says > The hydroxychloroquine group also had a strong but not statistically significant trend towards worsening NLR (p=0.051). So I believe they just accidentally moved the decimal place, and they are correctly avoiding calling the result statistically significant, but it is close.