4 ms·

Source? HCQ has been used for a long time. It is a medication that is usually ordered for chronic conditions. So people might be expected to be on HCQ for YEA

Source? HCQ has been used for a long time. It is a medication that is usually ordered for chronic conditions. So people might be expected to be on HCQ for YEARS. (Unlike COVID were they could be on the same doses for just days.) It has a well documented side effect profile and drug interact profile known well before COVID came onto the scene.

smt88 7y ago
> It has a well documented side effect profile and drug interact profile known well before COVID came onto the scene. You could have said the same about using aspirin to treat the flu, which we now know can be very dangerous[1]. Drugs also "interact" with diseases, leading to different (side) effects in patients with that disease than without it. 1. https://www.mayoclinic.org/diseases-conditions/reyes-syndrome/symptoms-causes/syc-20377255 https://www.mayoclinic.org/diseases-conditions/reyes-syndrom...
wyxuan 7y ago
Et voila: https://www.biorxiv.org/content/10.1101/2020.03.31.018556v1.full.pdf https://www.biorxiv.org/content/10.1101/2020.03.31.018556v1.... Also here's a source on the ventilator time: https://www.dropbox.com/s/8b2govfsa6n0xbq/NEJM_Clinical%20Outcomes%20of%20Hydroxychlorquine%20in%20Patients%20with%20COVID19.pdf.pdf.pdf.pdf?dl=0 https://www.dropbox.com/s/8b2govfsa6n0xbq/NEJM_Clinical%20Ou...
- honksillet 7y ago
  Interesting but not sure how generalizable a study on genetically modified mice is. I threw HCQ and metformin into the Epocrates drug interaction checker and this is what I got back, "Monitor glucose: combo may incr. risk of hypoglycemia, including life-threatening (additive effects)"
- JonathonW 7y ago
  I find it strange that this would be a new discovery, considering that even a casual search shows a decently large body of research specifically into the combinations of chloroquine and hydroxychloroquine with metformin.
- honksillet 7y ago
  "Confidential: Destroy when review is complete" A look behind the curtain.
  - wyxuan 7y ago
    Yep. Ding ding ding! Tried to post this link onto hn but it couldn't accept for some reason. This was a leaked paper submitted to NEJM.
voxl 7y ago
Why did you ask for a source while simultaneously making claims without sources? The drug is being falsely pushed by the deranged leader of the United States, I would be much more suspicious of you then of anyone claiming to be wary of it. Especially after Dr. Fauci himself told everyone on national television to not get there hopes up about it.
- lazyjones 7y ago
  HCQ is already widely used against COVID-19 around the world.
  - wyxuan 7y ago
    And yet deaths still keep going up. Usage is not a metric for effectiveness.
    - lazyjones 7y ago
      It's a treatment, not a cure. Deaths go up because more people are getting infected.
- honksillet 7y ago
  Please leave politics out of this. The OP was making very specific claims and I asked for the sources, which he provided. I thought it was common knowledge that HCQ is most often prescribed for chronic conditions (but I could be wrong about that). It is fair to ask for a source though so here is a source. https://reference.medscape.com/drug/plaquenil-hydroxychloroquine-sulfate-343205 https://reference.medscape.com/drug/plaquenil-hydroxychloroq... Note that for treatment of, say, Rheumatoid Arthritis the treatment duration is indefinite. The suggested dose for off label use of HCQ with covid is a single dose of 800mg, then 4 to 7 days of 400 mg. (That is from the Epocrates app on my phone so I don't have a link to share.)
  - giardini 7y ago
    honksillet says>"The suggested dose for off label use of HCQ with covid is a single dose of 800mg, then 4 to 7 days of 400 mg. "< 800 MG HCQ seems high. Dr. Zev Zelenko (https://www.youtube.com/watch?v=4ulqf5NXhms https://www.youtube.com/watch?v=4ulqf5NXhms) suggested a regimen for covid-19 with only half that dosage: - 200mg 2x daily Hydroxychloroquine, - 500mg 1x daily Azithromycin, - 220mg 1x daily Zinc sulfate.

smt88 7y ago

> It has a well documented side effect profile and drug interact profile known well before COVID came onto the scene. You could have said the same about using aspirin to treat the flu, which we now know can be very dangerous[1]. Drugs also "interact" with diseases, leading to different (side) effects in patients with that disease than without it. 1. https://www.mayoclinic.org/diseases-conditions/reyes-syndrome/symptoms-causes/syc-20377255 https://www.mayoclinic.org/diseases-conditions/reyes-syndrom...

wyxuan 7y ago

Et voila: https://www.biorxiv.org/content/10.1101/2020.03.31.018556v1.full.pdf https://www.biorxiv.org/content/10.1101/2020.03.31.018556v1.... Also here's a source on the ventilator time: https://www.dropbox.com/s/8b2govfsa6n0xbq/NEJM_Clinical%20Outcomes%20of%20Hydroxychlorquine%20in%20Patients%20with%20COVID19.pdf.pdf.pdf.pdf?dl=0 https://www.dropbox.com/s/8b2govfsa6n0xbq/NEJM_Clinical%20Ou...

honksillet 7y ago
Interesting but not sure how generalizable a study on genetically modified mice is. I threw HCQ and metformin into the Epocrates drug interaction checker and this is what I got back, "Monitor glucose: combo may incr. risk of hypoglycemia, including life-threatening (additive effects)"
JonathonW 7y ago
I find it strange that this would be a new discovery, considering that even a casual search shows a decently large body of research specifically into the combinations of chloroquine and hydroxychloroquine with metformin.
honksillet 7y ago
"Confidential: Destroy when review is complete" A look behind the curtain.
- wyxuan 7y ago
  Yep. Ding ding ding! Tried to post this link onto hn but it couldn't accept for some reason. This was a leaked paper submitted to NEJM.

voxl 7y ago

Why did you ask for a source while simultaneously making claims without sources? The drug is being falsely pushed by the deranged leader of the United States, I would be much more suspicious of you then of anyone claiming to be wary of it. Especially after Dr. Fauci himself told everyone on national television to not get there hopes up about it.

lazyjones 7y ago
HCQ is already widely used against COVID-19 around the world.
- wyxuan 7y ago
  And yet deaths still keep going up. Usage is not a metric for effectiveness.
  - lazyjones 7y ago
    It's a treatment, not a cure. Deaths go up because more people are getting infected.
honksillet 7y ago
Please leave politics out of this. The OP was making very specific claims and I asked for the sources, which he provided. I thought it was common knowledge that HCQ is most often prescribed for chronic conditions (but I could be wrong about that). It is fair to ask for a source though so here is a source. https://reference.medscape.com/drug/plaquenil-hydroxychloroquine-sulfate-343205 https://reference.medscape.com/drug/plaquenil-hydroxychloroq... Note that for treatment of, say, Rheumatoid Arthritis the treatment duration is indefinite. The suggested dose for off label use of HCQ with covid is a single dose of 800mg, then 4 to 7 days of 400 mg. (That is from the Epocrates app on my phone so I don't have a link to share.)
- giardini 7y ago
  honksillet says>"The suggested dose for off label use of HCQ with covid is a single dose of 800mg, then 4 to 7 days of 400 mg. "< 800 MG HCQ seems high. Dr. Zev Zelenko (https://www.youtube.com/watch?v=4ulqf5NXhms https://www.youtube.com/watch?v=4ulqf5NXhms) suggested a regimen for covid-19 with only half that dosage: - 200mg 2x daily Hydroxychloroquine, - 500mg 1x daily Azithromycin, - 220mg 1x daily Zinc sulfate.