I've used inkscape regularly for large print scientific posters for many years. It definitely used to struggle in that regard. It's gotten significantly bette

I've used inkscape regularly for large print scientific posters for many years. It definitely used to struggle in that regard. It's gotten significantly better about handling high resolution figures and using many layers in recent years. At least on Linux, it's quite capable of handling complex files, though deeply nested layers are fundamentally a bit clunky in the UI. (Inkscape is more focused on using groups the way layers are sometimes used in Illustrator. Layers are really just a named group under the hood, if that makes sense. At any rate, it's often best to rethink your workflows a bit if you're used to having illustator files with several hundred nested layers. The UI in Inkscape semi-deliberately discourages that workflow, while Illustrator deliberately encourages it.) Printing calibrated colors isn't it's strongest suit -- I'd recommending exporting and using something else for the actual final print. However, that may have changed too. I haven't tried recently -- I've mostly taken the "export to PDF and tweak the profile when printing the PDF" approach.