Not sure if you are aware of "dissipative energy systems", a possible top down principle: https://www.quantamagazine.org/a-new-thermodynamics-theory-of-the-ori

Not sure if you are aware of "dissipative energy systems", a possible top down principle: https://www.quantamagazine.org/a-new-thermodynamics-theory-of-the-origin-of-life-20140122/ https://www.quantamagazine.org/a-new-thermodynamics-theory-o... https://www.quantamagazine.org/first-support-for-a-physics-theory-of-life-20170726/ https://www.quantamagazine.org/first-support-for-a-physics-t... https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5686405/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5686405/