4 ms·

It's fine to speculate, but there is no real connection between these ideas and COVID beyond pure speculation. Vasodilation is not the issue with the lungs (unl

It's fine to speculate, but there is no real connection between these ideas and COVID beyond pure speculation. Vasodilation is not the issue with the lungs (unless you mean V/Q mismatch for specific vascular beds, in which case this is the accepted dogma and is unrelated to pulmonary hypertension). The other hypotheses are at the level of preclinical evidence. Some (e.g., zinc deficiency being a common cause of causing heart disease) would upend all known clinical data.

podgaj 7y ago
Yes, speculation is the fertilizer of hypothesis. All anyone has at this point with COVID is speculation. How can you say vasodialtion is not a vector in COVID19 outcomes? It is vasodialtion that increases capillary permeability leading to fluid in the intercistal space, am I correct? I may be wrong because I am reading that they are showing signs it appears as HAPE initially. https://www.ncbi.nlm.nih.gov/pubmed/32226695 https://www.ncbi.nlm.nih.gov/pubmed/32226695 But these patients, from what I have read, also see a dramatic drop in blood pressure at some point as well. so the connection with zinc is that they also treat HAPE patients with ACE2 https://www.ncbi.nlm.nih.gov/pubmed/22441085 https://www.ncbi.nlm.nih.gov/pubmed/22441085 ACE2 uses Zinc as a cofactor. So a zinc deficiency could mean less ACE2 and a greater risk of HAPE. Regarding zinc and heart disease, I am not saying it is THE cause, just a part of the cause. It is demonstrated very well that zinc deficiency is common in people with diabetes and heart disease. The clinical data is there, I just showed you part of it. Here is a great study, 2017, establishing a clear link beween zinc deficiency and diabetes: https://www.ncbi.nlm.nih.gov/pubmed/28138861 https://www.ncbi.nlm.nih.gov/pubmed/28138861 It still shocks me that in 2020 we still have people that think vitamin cofactors play no role in health and should be ignored.
- carbocation 7y ago
  You were talking in favor of pulmonary hypertension and now you’ve shifted. And you’re pushing vitamin deficiencies as some cause-all. I’m not continuing this discussion with you.
  - podgaj 7y ago
    james, I see you are a "cardiology fellow at the Massachusetts General Hospital in Boston and a research fellow in cardiovascular genetics at the Broad Institute in Cambridge, MA." Do you think you are talking to a nobody? I interfaced with some of your colleagues. So i cannot understand your reaction to my diusucssing zinc because the Broad Institute is creating a pro-drug that is in fact zinc to treat diabetes. Or as they put it "Going all metal on diabetes" https://www.broadinstitute.org/news/research-roundup-march-20-2020 https://www.broadinstitute.org/news/research-roundup-march-2... Hey, isn't there a connection between diabetes and heart disease? James, you are not a researcher, you are a serial capitalist. That you cannot see that the link between zinc and COVID is a possibility means that you are probably just stealing my ideas. But hey, that is where science is these days. And for those who wish to believe the nonsense that zinc plays no role in CVD, please read this: https://www.nature.com/articles/aps201825 https://www.nature.com/articles/aps201825 The association between zinc deficiency and the development of cardiovascular diseases (CVDs) has been supported by numerous studies. Supplementing zinc can reduce the risk of atherosclerosis and protect against myocardial infarction and ischemia/reperfusion injury.
  - podgaj 7y ago
    You think I shifted, but I did not. If you would have given me an opportunity I would have explained.
- deleted 7y ago
  [deleted]

podgaj 7y ago

Yes, speculation is the fertilizer of hypothesis. All anyone has at this point with COVID is speculation. How can you say vasodialtion is not a vector in COVID19 outcomes? It is vasodialtion that increases capillary permeability leading to fluid in the intercistal space, am I correct? I may be wrong because I am reading that they are showing signs it appears as HAPE initially. https://www.ncbi.nlm.nih.gov/pubmed/32226695 https://www.ncbi.nlm.nih.gov/pubmed/32226695 But these patients, from what I have read, also see a dramatic drop in blood pressure at some point as well. so the connection with zinc is that they also treat HAPE patients with ACE2 https://www.ncbi.nlm.nih.gov/pubmed/22441085 https://www.ncbi.nlm.nih.gov/pubmed/22441085 ACE2 uses Zinc as a cofactor. So a zinc deficiency could mean less ACE2 and a greater risk of HAPE. Regarding zinc and heart disease, I am not saying it is THE cause, just a part of the cause. It is demonstrated very well that zinc deficiency is common in people with diabetes and heart disease. The clinical data is there, I just showed you part of it. Here is a great study, 2017, establishing a clear link beween zinc deficiency and diabetes: https://www.ncbi.nlm.nih.gov/pubmed/28138861 https://www.ncbi.nlm.nih.gov/pubmed/28138861 It still shocks me that in 2020 we still have people that think vitamin cofactors play no role in health and should be ignored.

carbocation 7y ago
You were talking in favor of pulmonary hypertension and now you’ve shifted. And you’re pushing vitamin deficiencies as some cause-all. I’m not continuing this discussion with you.
- podgaj 7y ago
  james, I see you are a "cardiology fellow at the Massachusetts General Hospital in Boston and a research fellow in cardiovascular genetics at the Broad Institute in Cambridge, MA." Do you think you are talking to a nobody? I interfaced with some of your colleagues. So i cannot understand your reaction to my diusucssing zinc because the Broad Institute is creating a pro-drug that is in fact zinc to treat diabetes. Or as they put it "Going all metal on diabetes" https://www.broadinstitute.org/news/research-roundup-march-20-2020 https://www.broadinstitute.org/news/research-roundup-march-2... Hey, isn't there a connection between diabetes and heart disease? James, you are not a researcher, you are a serial capitalist. That you cannot see that the link between zinc and COVID is a possibility means that you are probably just stealing my ideas. But hey, that is where science is these days. And for those who wish to believe the nonsense that zinc plays no role in CVD, please read this: https://www.nature.com/articles/aps201825 https://www.nature.com/articles/aps201825 The association between zinc deficiency and the development of cardiovascular diseases (CVDs) has been supported by numerous studies. Supplementing zinc can reduce the risk of atherosclerosis and protect against myocardial infarction and ischemia/reperfusion injury.
- podgaj 7y ago
  You think I shifted, but I did not. If you would have given me an opportunity I would have explained.
deleted 7y ago
[deleted]