I have a slightly different motivation for asking that question. It's not (false) humility. Instead, I want to avoid a situation where the interviewer thinks "O

I have a slightly different motivation for asking that question. It's not (false) humility. Instead, I want to avoid a situation where the interviewer thinks "Obviously, he wouldn't know about that" and either doesn't ask at all or the conversation moves along before we talk much about it. For example, I talked to someone on Friday about a bioinformatics job. In passing, the manager remarked, "So you probably don't have any experience analyzing gene networks...." While that's true, I have done other graph theory/network analysis work that uses the same mathematical tools, so we talked about that for a bit. Without that offhand comment, though, I'm not sure how I would have gone about making my case.