4 ms·

No randomized control group. Without one all that these findings mean is "go get more data".

by svara 7y ago

VectorLock 7y ago
Any data point has value if properly interpreted. More data is always better.
- deleted 7y ago
  [deleted]
Frost1x 7y ago
They also mean "advertising opportunity in the face of ignorance." Due to general systemic issues of incentives and disincentives to research (especially tied to profit driven entities but its everywhere) that are growing ever more problematic, successes are often painted more vibrant and failures toned down, usually through loose/generalized language in summaries or by adding so many quantifiable qualifiers to the situation/experiment at hand, the results become nearly useless. Research is not incentivized to give unbiased truth of failures the way science should be. They focus on optimistic results and try to gloss over negative results (have to pay rent and keep eating). The truth usually requires reading through a full paper because while forming narratives is commonplace, pure academic dishonesty is not. Research results typically do not forge or falsify results. Even in a humanitarian perfect situation where Gilead is pushing the supply of this out for free, I can assure you managers and purse holders want to see positive results. If you're a research scientist working at Gilead, I highly suspect you're going to be encouraged to show positive optimistic results, not problems/shortcomings (as in most business environments). If you do show negative results, they won't see the light of day if they're even read by management.
- vikramkr 7y ago
  It's not like you can go buy the drug on the open market. The fda are the gatekeepers, and as gilead states in the press release, they are currently running a large phase 3 study with a control group etc to confirm these results
vikramkr 7y ago
Which they're doing in a phase 3 with thousands of data points, as the press release states.

No randomized control group. Without one all that these findings mean is "go get more data".

by svara 7y ago

No randomized control group. Without one all that these findings mean is "go get more data".

VectorLock 7y ago

Any data point has value if properly interpreted. More data is always better.

deleted 7y ago
[deleted]

Frost1x 7y ago

They also mean "advertising opportunity in the face of ignorance." Due to general systemic issues of incentives and disincentives to research (especially tied to profit driven entities but its everywhere) that are growing ever more problematic, successes are often painted more vibrant and failures toned down, usually through loose/generalized language in summaries or by adding so many quantifiable qualifiers to the situation/experiment at hand, the results become nearly useless. Research is not incentivized to give unbiased truth of failures the way science should be. They focus on optimistic results and try to gloss over negative results (have to pay rent and keep eating). The truth usually requires reading through a full paper because while forming narratives is commonplace, pure academic dishonesty is not. Research results typically do not forge or falsify results. Even in a humanitarian perfect situation where Gilead is pushing the supply of this out for free, I can assure you managers and purse holders want to see positive results. If you're a research scientist working at Gilead, I highly suspect you're going to be encouraged to show positive optimistic results, not problems/shortcomings (as in most business environments). If you do show negative results, they won't see the light of day if they're even read by management.

vikramkr 7y ago
It's not like you can go buy the drug on the open market. The fda are the gatekeepers, and as gilead states in the press release, they are currently running a large phase 3 study with a control group etc to confirm these results

vikramkr 7y ago

Which they're doing in a phase 3 with thousands of data points, as the press release states.