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A Danish study recently concluded that actual infection rates could be 30x-80x higher than what is shown by positive test results. This could easily explain the
by ping_pong 7y ago
A Danish study recently concluded that actual infection rates could be 30x-80x higher than what is shown by positive test results. This could easily explain the higher levels than expected and is potentially a good thing and bad thing. It means that mortality is much much lower that expected.
https://www.reddit.com/r/COVID19/comments/fxk917/covid19_in_denmark_status_entering_week_6_of_the/fmuw8a8/ https://www.reddit.com/r/COVID19/comments/fxk917/covid19_in_...
(Google translation)
Google translate of section 4.1.2 (pg.27):
4.1.2. Revised planning basis Statens Serum Institut informs on the basis of antibody studies in 1,000 blood donors in the Capital Region, lost in the period 1-3. In April, 2.7% had been detected with antibodies, which, with a sensitivity of 70%, corresponds to 3.5% of those examined had already been infected with COVID-19. Statens Serum Institut states that if this figure is transmitted to the entire population of the Capital Region, it is equivalent to approx. 65,000 people may have been infected as early as 26 March. At this time, 917 confirmed cases of infection were found in the region. This means that there can be up to 70 times more infected in the community than confirmed cases.
In the work of the State Serum Institute in modeling the development of the epidemic in Denmark, on the basis of studies in, among other things, Iceland and Germany, it has been decided to work with the real number of infected in Denmark being 30-80 times higher than the number that remains. ver proven.
It is therefore estimated that the dark number is significantly higher than in the first planning scenario, and it is estimated from the State Serum Institute that for every detected infection case up to March 28, there may be 30-70, which are actually infected. This ratio will be affected by the number of people who will be infected in the future.
Thus, there is probably much more widespread contagion in society than previously thought. This does not have a direct impact on the planning basis for the health care system, as the increased spread of infection is in a part of the population who do not need hospital treatment and probably only to a very limited extent have sought medical attention. It should also be noted that it also means that the mortality rate of infection with SARS-CoV-2 (infection fatality rate, IFR) is lower than the mortality rate of registered case fatality rate (CFR) and possibly lower than that of WHO have evaluated. The WHO has estimated that the IFR is between 0.3-1.0 with wide variation across age groups. With more precise knowledge of the dark figures, the IFR for the COVID-19 epidemic in Denmark can be clarified and the expected mortality will be accurately estimated.
The State Serum Institute states that over the coming weeks they will be able to continuously monitor the development of immunity in the population through cooperation with the blood banks, focused sample studies and testing for the population's immune status in general.
The above also means that the previous assessment of the mortality in connection with COVID-19 in Denmark is no longer true. When a more accurate assessment of the actual prevalence of infection is obtained on the basis of the epidemiologic surveillance and a precise IFR for the Danish epidemic is estimated, a new and true mortality prognosis can be estimated.
The need for ordinary beds and intensive beds is evident from the modeling, which will be continuously qualified.
TLDR: blood donor antibody testing indicates true infection rates are 30x-80x higher than confirmed cases in Denmark and that 1.5 weeks ago ~3.5% of Copenhagen’s population may have already been infected by Covid-19.
- Symmetry 7y agoThe relationship between the number of infections and the number of confirmed cases is going to be hugely dependent on the number of tests and how they are distributed. 80x higher is very plausible but the ratio is going to be very country dependent. I'd be rather surprised if South Korea was more than 2x off, but I could easily see Ethiopia being 5000x off right now.
- guscost 7y agoLooks like South Korea has administered fewer tests per capita than Denmark, but you're right that their numbers could be closer if those tests were more effectively targeted.
- Symmetry 7y agoIf you have fewer infections and are able to allocate your tests to people who came into contact with those infected then you need fewer tests.
- 0xFFC 7y agoWhile what you are saying is logically coherent but it does not work in the real world. How are you going to track all the people the infected people has to contact with? How about asymptotic cases?
- Symmetry 7y agoYou don't have to be perfect, just good enough to get R under 1. It's been working pretty well Taiwan, Singapore, and South Korea when combined with moderate social distancing measures.
- guscost 7y agoGood to see that these results are starting to come out. Eagerly awaiting results of the Stanford serosurvey and others. I'm an optimist but maybe we can hit 100x!