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> All the attenuated live viral vaccines spread. Can you point me to sources supporting that claim? I searched myself, and what I found says that our knowledge
by scott_s 7y ago
> All the attenuated live viral vaccines spread.
Can you point me to sources supporting that claim? I searched myself, and what I found says that our knowledge is limited to the polio vaccine:
"Little attention has been given to vaccine transmission, possibly because transmission is rarely measured and largely unknown in humans except for the oral polio vaccine. Whether transmission is indeed rare for other live vaccines, or has merely gone unnoticed, is not clear – polio vaccine transmission is accompanied by evolution to high virulence, creating problems that draw attention to transmission."
From "Transmissible Viral Vaccines", James J. Bull et al., Trends in Microbiology, January 2018. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5777272/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5777272/
- LyndsySimon 7y agoThis is a difficult topic to research these days due to the anti-vax/anti-anti-vax noise. :( It doesn’t appear that horizontal transfer is absurd, and while I’m not immediately seeing a large body of evidence that it happens all the time, it does seem to be generally accepted that it occurs. Here’s what I believe to be an informative article on the topic: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3667938/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3667938/