True, dilution is a challenge but the assays used for COVID19 detection generally have a pretty wide dynamic range (3-5 orders of magnitude). The multiplex des

True, dilution is a challenge but the assays used for COVID19 detection generally have a pretty wide dynamic range (3-5 orders of magnitude). The multiplex designs in Origami Assays mix between 4 (for S3) and 36 (for XL3) samples per well, depending on design. This means that samples are diluted by a max of 1:36 in the largest XL3 design (2.8% original concentration) so the assay used must be able to handle that. Alternatively, samples may be concentrated depending on the specific assay.