4 ms·
Evolving a cure for Covid-19 using computationally guided antibody discovery
--
I could not find a single link that nicely summed up the effort happening at Distributed Bio / Centivax - With that in mind, here are a few different pages and videos about this interesting project.
--
Announcement about successfully engineering potent picomolar antibodies that block known neutralizing ACE2 epitopes, preventing the novel coronavirus from infecting human cells.
https://www.youtube.com/watch?v=BzX2qlyn_MM
A video about how they are using ML to analyze and mutate their existing CoV1 antibodies to block CoV2.
https://www.youtube.com/watch?v=LkbycGC_fsQ
A Centivax page (not sure how it fits with Distributed Bio but seems to be connected) that explains the project as a whole.
https://www.centivax.com/covid19
A page that describes the underlying effort to engineer monoclonal therapeutics against 21st-century pathogens through computationally guided antibody discovery.
https://www.centivax.com/monoclonals
This all sounds very hopeful and interesting to me. That said, it would be great to hear from some folks on HN who have a deeper understanding of all of this.